Friday 24 May 2024

Parkinson's Disease Treatment History

 


Only more about Parkinson’s. I open my Parkinson’s and we are at a part about treatment, so let’s see what we can learn.

Treating PD with drugs has only been around for a roughly one hundred and something years, and the most effective drugs didn’t come about till after the second world war. It was the drugs introduced only 40 odd years ago that have made an enormous impact on the lives of those with PD.

Even though it was 1817 when James Parkinson identified the disease, it wasn’t till the late 1880’s that neurologists in Paris discovered that drugs derived from the Belladona group of plants gave some relief from rigidity and tremor. These simple drugs were the main treatment till the 1940’s, when chemically synthesized and concentrated agents replaced them, as they worked in the same way.

This group, known as anticholinergics, meant that for the first time a drug for the treatment of PD was widely available. These drugs can still be found in use today but much less with the discovery of drugs called the dopaminergic which replaces the most important chemical deficiency in the brain.

It was in the 1960’s that scientists in Vienna identified a link between PD and a deficiency in dopamine which led to the use of levodopa. Levodopa is the natural chemical precursor of dopamine. So, it became the first dopamine-active drug shown to be effective in treating PD.

Natural with these drugs come side effects and said side effects can really affect some people, while others don’t get any side effects. How some people deal how some people are affected can change over time as many will be receiving treatment for years or decades.

It is for these reasons that medication needs to be monitored by a doctor preferrable a neurologist or movement disorder specialist.

Because treatment is ongoing and taking one simple tablet may not help many are on combination of drugs and the dosage and frequency of the medication will need to be changed at different times over the years.

More to come next week.

18 comments:

  1. Sounds like a complicated trial and error system to find medications that work and keep working. I hope you find what works the best for you. :)

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    1. What I am taking now seems to be working

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    2. Thank the Lord for that! I am glad to read that from you.

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  2. Must be so hard to get the correct drug for a person - hopefully one day there will be a cure Jo-Anne.

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    1. Maybe one day there will be a cure but I doubt it will be in my lifetime

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  3. I imagine everyone is different, so everyone has to have a specific program after years of trial and error ... and then it changes again. I wish they could just find a cure.

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    1. Yes it is truly trial and error trying to find the right mix

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  4. Thank you for sharing this. I am glad that they did find something that helps. I know that I have to take drugs for several things and I have side effects very often with different drugs we have tried.

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    1. Side effects are part of the mix but thankfully I have none with my meds at this time

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  5. The journey of Parkinson's disease treatment is truly remarkable, reflecting the tireless efforts of medical science to improve the lives of patients. It's fascinating to learn about the evolution of medications from plant-derived compounds to chemically synthesized agents, ultimately leading to the development of dopamine-active drugs like levodopa. Your insights shed light on the complexities of managing PD symptoms and the importance of close medical supervision to tailor treatment regimens for each individual. Thanks for sharing this valuable information!

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    1. I am pleased you liked the post, I also find it fascinating how these treatments come about

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  6. There is probably still a long way to go to find the right medication today.

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    1. I believe so, and longer still till we have a cure

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  7. It is disappointing that after so many years there are still no medications to help control the disease.

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  8. It has seemed to me that there is a good deal of research still on going and for that I am grateful. Two of my dearest friends had Parkinsons.

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    1. At least they are trying to find better ways to treat it

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